Humanized mice develop coronavirus respiratory disease

Humanized mice

Animal models have been instrumental in increasing the understanding of human physiology, particularly immunity. However, these animal models have been limited by practical considerations and genetic diversity. The creation of humanized mice that carry partial or complete human physiological systems may help overcome these obstacles. The National Institute of Allergy and Infectious Diseases con...

middle east respiratory syndrome coronavirus

Study of the Clinical and Radiologic findings of Middle East Respiratory Syndrome and Coronavirus Disease-2019

Aim and Background: Severe Acute Respiratory Syndrome Corona Virus (SARS-CoV-2) is a single-strand RNA, β‐coronavirus with mostly respiratory symptoms responsible for Corona Virus Disease (COVID-19), which causes a pandemic worldwide. This novel coronavirus is associated with severe pneumonia and Acute Respiratory Distress Syndrome (ARDS). Middle East Respiratory Syndrome (MERS-CoV) is another ...

Coronavirus infection in acute lower respiratory tract disease of infants.

The 1974 article by my colleagues and me describing studies of coronavirus infection in hospitalized infants with acute lower respiratory–tract disease (LRTD) [1] takes on a particular interest in light of the 2002–2003 epidemic of severe acute respiratory syndrome (SARS) coronavirus infections, with the wider perspective provided by that event on emerging epidemics, acute respiratory infection...

A previously undescribed coronavirus associated with respiratory disease in humans.

The etiology of acute respiratory tract illnesses is sometimes unclear due to limitations of diagnostic tests or the existence of as-yet-unidentified pathogens. Here we describe the identification and characterization of a not previously recognized coronavirus obtained from an 8-mo-old boy suffering from pneumonia. This coronavirus replicated efficiently in tertiary monkey kidney cells and Vero...